OMTX705

OMTX705 is an ADC formed by a new humanized anti-FAP mAb that has been conjugated to a novel cytolysin, TAM470, a synthetic microtubule inhibitor from the tubulysin family. OMTX705 is designed to target FAP-expressing Cancer Associated Fibroblasts (CAFs) in tumor microenvironment. 

The FAP protein is used as a docking for OMTX705 so that, upon FAP binding onto the CAF cell membrane, the agent is internalized and transported to intracellular late endosome where the cytotoxic moiety is released. The targeting of CAFs and the associated stroma modulation would then delay disease progression, increase drug penetration, and reestablish the tumor immune response to anti-PD-1 therapy.
 

OMTX705 is intended for the treatment of patients with advanced solid tumors known to have FAP-expressing CAFs: PDAC, GC, HNSCC, EC, NSCLC, HGSOC, BC,CRC, and leiomyosarcoma.